![]() ![]() Prohibitively costly UHPLC systems are created in accordance with sub-2 particle, high pressure applications. The difference between core-shell technologies and UHPLC systems In terms of size and shape, core-shell particles are remarkably constant, which also helps to enhance separation efficiency by limiting variable analyte movement between the particles. (In order to increase efficiency it’s important to minimise sources of band broadening, such as diffusion). This is because diffusion only occurs via the porous, outer layer of the particle rather than the entire particle. Core-shell particles and high separation efficiencyĬore-shell particles’ high separation efficiency is largely due to more rapid analyte mass transfer – from the mobile phase through to the stationary phase and back again. Instead of investing in a costly UHPLC system, many labs are choosing to improve the efficiency of their existing HPLC system, increasing efficiency and reducing expenses in one fell swoop. Used in conjunction with high mobile phase flow rates, core-shell particles can reduce the amount of analysis time without impacting upon rates of separation efficiency or generating extreme back-pressures. While this may sound tricky, core-shell technologies provide a low-pressure, high efficiency solution to this particular problem. Today, the vast majority of chromatographers seek to lower costs and increase productivity simultaneously. ![]()
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